Olanzapine/samidorphan will decrease the extent or effect of hydromorphone by pharmacodynamic antagonism. Contraindicated. Samidorphan elicits opioid antagonistic consequences and will increase threat of precipitating acute opioid withdrawal in people dependent on opioids. Respiratory depression can arise at any time through opioid therapy, specially when initiating and next dosage wi... https://hughv045wlw2.wikicorrespondence.com/user