You will find there's release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to reduce afferent discomfort transmission and develop analgesia. Hence, medication like clonidine that focus on alpha-two receptors can impact the transmission of ache. Clonidine is a protracted-phrase medication. https://dennisj269vsp1.wikistatement.com/user