Epidural clonidine used as an adjunct to regional anesthetics has three different mechanisms of motion. Initially, the stimulation of alpha-2-receptors from the dorsal horn lessens soreness transmission. Secondly, clonidine may cause regional vasoconstriction that limitations vascular elimination of local epidural anesthetics. This document will not include all probable interactions. https://isaacs948tzb7.wikicorrespondence.com/user