During the LSD-certain crystal framework, the facet chain on the lid residue L209EL2 forms extensive hydrophobic contacts with both LSD and encompassing residues in TMs III, IV, and V (Figure 4C). When the lid moved aside to show the binding pocket in simulation, quite a few of those contacts broke. https://sethdjcba.blogspothub.com/34156143/facts-about-limited-edition-exclusive-lsd-crystal-revealed