Topoisomerase II is critical for DNA replication. transcription and chromosome segregation and is a well validated target of anti-neoplastic drugs including the anthracyclines and epipodophyllotoxins. However. these drugs are limited by common tumor resistance mechanisms and side-effect profiles. https://www.markbroyard.com/super-save-whole-wheat-phyllo-pastry-sheets-jufka-sa-integralnim-brasnom-12pcs-x-450g-jami-supply-great-choice/