There is a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to decrease afferent suffering transmission and develop analgesia. Hence, medications like clonidine that concentrate on alpha-two receptors can impact the transmission of ache. Clonidine is distributed in breast milk; https://www.proleviate.com/post/the-new-pain-killer-conolidine